The course aims to provide knowledge and practical skills for the creation and utilization of Digital Twins, covering fundamental concepts and technologies, Industry 4.0 applications, modeling of physical objects and processes, photogrammetry, machine learning and deep learning techniques, large language models, as well as applications of the Industrial Internet of Things, smart buildings, and sustainability. In addition, the course examines the use of Digital Twins in the Cultural and Creative Industries through real-world case studies.